- often multiple
- seen in two-thirds of patients with Carney complex
- skin pigmentation (blue nevi): especially of the face, trunk, lips, and sclera
Multiple other features are also well recognized including:
- extracardiac myxoma
- adrenal gland: primary pigmented nodular adrenocortical disease (PPNAD)
- pituitary adenoma
- psammomatous melanotic schwannoma
- Sertoli cell tumors: most common
Carney complex has autosomal dominant inheritance related to mutation of the PRKAR1A tumor suppressor gene on chromosome 17q 5.
One way to remember the differentiation between the Carney triad and the Carney complex is that the Carney Complex has Cardiac findings (myxoma).
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