CLOVES syndrome

Dr Henry Knipe and Dr Matt A. Morgan et al.

CLOVES syndrome is an acronym denoting a rare condition consisting of:

  • Congenital Lipomatous Overgrowth
  • Vascular malformations
  • Epidermal nevi
  • Skeletal/Scoliosis/Spinal anomalies

Terminology

Although first described as CLOVE the term "CLOVES" syndrome, with the "S" emphasizing the skeletal abnormalities associated with the condition, is now preferred. 

Pathology

The condition is considered an overgrowth syndrome, similar to, but separate from Proteus syndrome. Abnormalities have a truncal predominance. Associated findings include:

Genetics

It is associated with three different missense mutations in the PIK3CA gene 2

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Article information

rID: 32261
System: Paediatrics
Section: Syndromes
Synonyms or Alternate Spellings:
  • Congenital lipomatous overgrowth
  • CLOVES syndrome

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