Cobblestoning (having a cobblestone appearance) can occur in a number of hollow organs with mucosa, most commonly the bowel, in the setting of Crohn disease.
Longitudinal and circumferential fissures and ulcers separate islands of mucosa, giving it an appearance reminiscent of cobblestones.
Cobblestone appearance has been reported in:
- Crohn disease: small and large bowel
- candida esophagitis 1
- Hirschsprung disease 4
- eosinophilic gastritis 5
- Brunner gland hyperplasia of the duodenum 5
- nodular lymphoid hyperplasia in duodenal cap
Other disease processes can present with cobblestone-like imaging characteristics.
- 1. Yang GD, Lu PX, Qin J et-al. Radiologic diagnosis for AIDS patients complicated with candidal esophagitis. Chin. Med. J. 2011;124 (7): 965-7. Chin. Med. J. (abstract) - Pubmed citation
- 2. Valentini Anna Lia, Ludovico Muzii, Riccardo Marana et al. “Fallopian Tube Disease: The Cobblestone Pattern as a Radiographic Sign1.” Radiology 217, no. 2 (November 2000): 521-525. doi:VL - 217.
- 3. Barkovich AJ. Imaging of the cobblestone lissencephalies. AJNR Am J Neuroradiol. 1996;17 (4): 615-8. AJNR Am J Neuroradiol (citation) - Pubmed citation
- 4. O'donovan AN, Habra G, Somers S et-al. Diagnosis of Hirschsprung's disease. AJR Am J Roentgenol. 1996;167 (2): 517-20. AJR Am J Roentgenol (abstract) - Pubmed citation
- 5. Fundamentals of Diagnostic Radiology. Lippincott Williams & Wilkins. (2012) ISBN:1451171390. Read it at Google Books - Find it at Amazon