Osteopathia striata

Dr Craig Hacking and Radswiki et al.

Osteopathia striata, also known as Voorhoeve disease, is a rare, benign sclerosing bone dysplasia, involving the epiphysis and metaphysis of tubular bones.

Oseopathia striata can be found in any age group. 

It is typically asymptomatic, although there can be associated joint discomfort.

There is an association with focal dermal hypoplasia (Goltz syndrome).

Osteopathia striata is typically bilateral, although occasionally it can be unilateral, typically in tubular bones.

Radiographically prominent vertical striations predominate in the metaphyses and epiphyses of the long bones (celery stalk metaphysis). 

Not infrequently there are shared features of melorheostosis and osteopoikilosi, in a so-called overlap syndrome termed mixed sclerosing bone dysplasia. These conditions may share an underlying etiology (loss of function mutations in the LEMD3 gene) 5.

The differential diagnosis includes:

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Article information

rID: 12269
Tag: cases, cases
Synonyms or Alternate Spellings:
  • Voorhoeve disease
  • Voorhoeve's disease

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Cases and figures

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