Pandystrophies are neurological diseases that involve both white and grey-matter involvement as opposed to leukodystrophies (dominated by white matter involvement) or poliodystrophies (dominated by grey matter involvement).

Most metabolic diseases with central nervous system involvement fall into this category, as exclusive white of gray matter involvement is quite uncommon.

For example, archetypal leukodystrophies such as Canavan disease or Krabbe disease, present pallido-thalamic and putaminal lesions, respectively.

In fact, a grey matter neuroimaging abnormality can be caused by myelin breakdown, and a white matter neuroimaging abnormality can be a reflexion of a secondary neuronal degeneration. 

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rID: 66869
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