Progressive multifocal leukoencephalopathy immune reconstitution inflammatory syndrome
Progressive multifocal leukoencephalopathy immune reconstitution inflammatory syndrome (PML-IRIS) is a form of immune reconstitution inflammatory syndrome (IRIS) seen in patients who are immunomodulated and develop an aggressive form of progressive multifocal leukoencephalopathy (PML).
Two types of PML-IRIS are recognized:
- PML-s-IRIS: simultaneous development of IRIS and PML due to immune reconstitution
- PML-d-IRIS: immune reconstitution worsens preexisting PML
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