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Cogan’s syndrome (CS) is the combination of episodic attacks of interstitial keratitis and audiovestibular disturbance due to autoimmune reaction to the eyes and the audiovestibular structures.



CS is a rare disorder that can occur in people of any age and race, and it most frequently starts in young adults in their late 20’s or early 30’s.


Clinical presentation


Inflammation of the eyes


audiovestibular dysfunction
  • nausea
  • vomiting
  • tinnitus
  • vertigo
  • hearing loss

Later on:

  • fatigue
  • headaches
  • joint pains
  • rashes


Hearing loss progresses for 1 to 3 months and deafness occurs in about 60% of patients.

Auditory symptoms can precede or follow eye disease, usually within a short period of time.


Atypical Cogan's syndrome (audiovestibular dysfunction with other types of inflammatory eye disease) is associated with vasculitis in 20% of cases and has a less favourable prognosis than typical Cogan's syndrome.



autoimmune reaction to the eyes and the audiovestibular structures possibly triggered by upper respiratory infection.




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See also


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