Breast biopsy is performed whenever it becomes necessary to characterize a breast lesion. This consists of the withdrawal and collection of cells (cytologic exam) or tissue fragments (histologic exam) and in the anatomical-pathological analysis of the sample tissue.
There are many different ways to perform the sampling depending on the type of guidance used to locate the breast lesion:
Stereotactic breast biopsy is the choice in the case of microcalcifications or non-palpable lesions only visible on mammograms.
Stereotactic breast biopsy
Stereotactic devices differ by imaging modality (analog vs digital), calculation of co-ordinates modality (manual or digital) and patient position (sitting or prone). However, any of these devices allow the performance of the biopsy with any type of needle, from fine ones used for FNAB (fine-needle aspiration biopsy) to special ones used for VACB (vacuum-assisted core biopsy) that require additional specific equipment (e.g. Mammotome™).
Patient position choice depends on the equipment.
In the prone position, the patient lies face down on a special bed with the breast protruding through a hole in bed surface. However, in the sitting position, the patient is in front of the equipment.
A prone position is widely preferred for many reasons mainly linked to patient reactions. It is not infrequent that patients may have a vagal response in the sitting position, due to the visualization of the needle introduction into her breast, rather than from emotional tension.
Targeting of lesion
A cranio-caudal projection is performed compressing the breast with a small special paddle with a central “window”.
Once the lesion is highlighted in the first mammogram, two additional projections are performed at +15 and -15 degrees. After marking the center of the lesion, it will be possible to calculate spatial coordinates X, Y and Z.
With the breast lightly compressed, the cutaneous entry point is identified. After having introduced the needle and verified the correct position of the lesion with further mammography projections, biopsy may be performed.
VACB: Vacuum-assisted core biopsy
A VACB stereotactic breast biopsy is performed as a diagnostic approach when mammography shows irregularities with micro-calcifications, parenchymal distortions, only micro-calcifications or <0.5 cm ill-defined nodules with or without micro-calcifications, all cases in which cytology can result as false-negative or provide inadequate material due to the preponderance of background connective tissue.
VACB allows for quick histology at a low cost. Furthermore, it avoids patient exposure to diagnostic surgical biopsy or long and exhausting follow-ups, making VACB an extremely valid method for diagnosis.
MammotomeTM VACB consists of a control unit which maintains aspiration at constant values (23-25 mm/Hg) and of a driver where an 11-14G needle is placed.
The system is linked to a computer where calculations are done regarding radiographic acquisitions according to stereotactic geometry principles, numerical values regulating placement and excursion of the needle to the lesion are transmitted to the driver.
The procedure is performed under local anesthesia (1% lidocaine).
An incision of 3-4 mm is usually made by a lancet to facilitate the introduction of the needle, which can rotate 360°. Such rotation is designed to work in an area of tissue about 1-2 cm in diameter (11G needle).
The needle tip is pushed into the lesion. The distance is controlled through an additional acquisition and corrected if necessary. Once targeting is done, the system is activated. Due to the vacuum, breast tissue is first drawn to a 19 mm length window present at the tip of the needle, cut by a high speed rotating blade and then dragged onto the drawing room placed at the proximal end of the handpiece needle-holder. The number of withdrawn samples can vary from 5 to 20. The average length is 20 mm, diameter 3 mm and a total weight approximately 1 g (per 12 samples).
All withdrawn samples are placed on a radio-transparent support, according to the direction in which each sample was taken (clockwise or counter-clockwise) and labeled to be x-rayed in order to verify the presence of micro-calcifications.
At the end of the procedure, a radiopaque and non-magnetic clip is placed on site for the future recognition of the biopsied region.
The cutaneous incision is dressed with a steri-strip tape and a compressive bandage is applied for 24 hours. A pack of instant ice is also applied.
- MammotomeTM VACB allows, with a single needle entry, the withdrawal of up to 20 samples (to obtain enough samples for the histological exam -at least 4-5 samples- with traditional core-biopsy the needle must be repositioned each time)
- MammotomeTM VACB allows a better quality samples withdrawal compared to core-biopsy (due to forced aspiration, the integrity of the samples is guaranteed and any hematic residue is eliminated
- MammotomeTM VACB allows any future stereotactic procedure or follow up to be easily manageable due to the titanium clip left in place
- the choice of an 11G needle makes it possible to withdraw twice the quantity of tissue compared to a 14G needle without a real increment in complications
Equipment, disposable consumables and needles are very expensive, but in terms of cost evaluation, the VACB should not be compared to FNAB, as the choice between both methods is not arbitrary but indicates a strict selection of the cases to expose to one or the other technique. This correct behavior makes the MammotomeTM VACB less expensive than a surgical biopsy or repetitive follow-up.
- vasovagal reaction: not usually experienced when a Mammotome device is used in the prone position
- hematoma formation: uncommon
- 1. Fajardo LL, Willison KM, Pizzutiello RJ. A comprehensive approach to stereotactic breast biopsy. Wiley-Blackwell. (1996) ISBN:0865424675. Read it at Google Books - Find it at Amazon
- 2. Singletary SE, Robb GL, Hortobagyi GN. Advanced therapy of breast disease. Pmph USA Ltd. (2004) ISBN:1550092626. Read it at Google Books - Find it at Amazon
- 3. Jackman RJ, Marzoni FA, Rosenberg J. False-negative diagnoses at stereotactic vacuum-assisted needle breast biopsy: long-term follow-up of 1,280 lesions and review of the literature. AJR Am J Roentgenol. 2009;192 (2): 341-51. doi:10.2214/AJR.08.1127 - Pubmed citation
- 4. Penco S, Rizzo S, Bozzini AC et-al. Stereotactic vacuum-assisted breast biopsy is not a therapeutic procedure even when all mammographically found calcifications are removed: analysis of 4,086 procedures. AJR Am J Roentgenol. 2010;195 (5): 1255-60. doi:10.2214/AJR.10.4208 - Pubmed citation
- 5. Pacifici S, Percutaneous stereotactic biopsy with Mammotome system: exam methodology and role of radiology technologist, at 2nd E-mcr, Malta 2007
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