Histology of gallbladder following routine cholecystectomy:
Low power of gallbladder wall (with mucosa facing left and serosa right).
The muscle wall is thickened with multiple prolapsed glands in the subserosal tissue (Rokitansky-Aschoff sinuses); the glands are variably dilated, including one containing fragmented 'orange/brown' material (inspissated bile).
Medium power - One of the glands contains inspissated bile, in areas starting to form aggregated clumps.
Medium power of gallbladder wall (mucosa top left). The angular, mildly dilated glands (Rokitansky-Aschoff sinuses) prolapse between muscle bundles, with presumed residual communication with the overlying mucosa, akin to colonic diverticula.