Acute malignant Marburg type multiple sclerosis

Discussion:

The above described constellation of findings are those brain demyelinating process with the right cerebellar hemisphere mass lesion conventional and spectroscopic criteria are very suggestive of tumefactive variant of multiple sclerosis (Marburg’s variant of MS).

Marburg multiple sclerosis is a sub-type of MS with only one lesion may be present. This lesion tends to be very large, and it can resemble a brain tumor or abscess. The associated brain demyelinating foci particularly those periventricular and corpus callosal lesions as well as the MRS findings in a young age female are very suggestive of the diagnosis of Marburg's variant of MS. 

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