Hereditary ataxia


The main differential daignoses in this case are:

  • chronic alcoholism: produces similar vermis (diffuse, not specifically superior) atrophy and extensive cerebellar atrophy; however, it wouldn't happen to such a young patient!
  • hereditary ataxia syndrome: vermis and cerebellar atrophy with brain atrophy
  • Salla's disease:  a rare autosomal recessive lysosomal storage disease  in which there is extensive vermian atrophy, corpus callosal thinning
  • lipofuscinoses

Hereditary cerebellar atrophy carries a broad differential and is discussed in greater details here: